Bone marrow ‐derived progenitor cells contribute to remodeling of the postpartum uterus

In conclusion, BM-derived progenitors were found to have a novel nonhematopoietic cellular contribution to postpartum uterus remodeling. This contribution may have an important functional role in p hysiological as well as pathological postpartum endometrial regeneration.© AlphaMed Press 2021Significance StatementThe uterus undergoes significant tissue regeneration in the postpartum period following parturition where endometrial stem cells are thought to play an important role. Here we show that bone marrow-derived progenitor cells actively participate in postpartum uterus remodeling in the mouse, undergoing dynamic changes and contributing to various non-immune endometrial cell populations as part of the process of cellular turnover and regeneration. These observations may have important implications for human uterine physiology and pathological conditions such as postpartum uterine scarring.

Source: Stem Cells - July 5, 2021 Category: Stem Cells Authors: Reshef Tal, Jacqueline Kisa, Nafeesa Abuwala, Harvey J. Kliman, Shafiq Shaikh, Alice Y. Chen, Fang Lyu, Hugh S. Taylor Tags: Tissue ‐Specific Stem Cells Source Type: research