Inhibition of iNOS as a novel effective targeted therapy against triple negative breast cancer

Conclusions:
Based on the effectiveness of L-NMMA in decreasing tumor growth and enhancing survival rate in TNBC, we propose a targeted therapeutic clinical trial by re-purposing the pan-NOS inhibitor L-NMMA, which has been extensively investigated for cardiogenic shock as an anti-cancer therapeutic.

Source: Breast Cancer Research - February 22, 2015 Category: Cancer & Oncology Authors: Sergio Granados-PrincipalYi LiuMaria GuevaraElvin BlancoDong ChoiWei QianTejal PatelAngel RodriguezJoseph CusimanoHeidi WeissHong ZhaoMelissa LandisBhuvanesh DaveSteven GrossJenny Chang Source Type: research