Comparison of a Modified Mid‐Coronal Sectioning Technique and Wilson's Technique when Conducting Eye and Brain Examinations in Rabbit Teratology Studies

CONCLUSIONSWhile both methods are equally sensitive at detecting common and rare developmental defects, the modified mid‐coronal sectioning technique eliminates the use of chemicals and concomitant fixation artifacts that occur with the Wilson's technique and allows for examination of 100% intact fetuses thereby increasing potential for detecting eye and brain alterations as these findings occur infrequently in rabbits

Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - December 1, 2014 Category: Perinatology & Neonatology Authors: Mary K. Ziejewski, Howard M. Solomon, Joyce Rendemonti, Dinesh Stanislaus Tags: Research Article Source Type: research