Endothelial dysfunction and metabolic syndrome in preeclampsia: an alternative viewpoint

Preeclampsia is a severe complication of human pregnancy that occurs in 3 to 5% of all pregnancies and may threaten maternal and fetal survival (Steegers et al., 2010). It is characterized by immunological alterations, systemic inflammation, endothelial dysfunction, and metabolic syndrome (Redman and Sargent, 2010; Redman et al., 2014). Preeclampsia presents with a pattern of typical clinical features (hypertension and proteinuria) and possible further manifestations (renal failure, HELLP syndrome, seizures), but the precise pathogenic mechanisms remain to be determined.

Source: Journal of Reproductive Immunology - February 21, 2015 Category: Allergy & Immunology Authors: Marco Scioscia, S. Ananth Karumanchi, Debra Goldman-Wohl, Pierre-Yves Robillard Source Type: research