Treatment with granulocyte colony-stimulating factor in patients with repetitive implantation failures and/or recurrent spontaneous abortions

The identification of colony-stimulating factors (CSF) is based on cell culture assays established by Metcalf, Sachs, and their assistants in the mid-1960s for hematopoietic progenitor cells (Metcalf, 1980, Sachs, 1987). Granulocyte colony-stimulating factor (G-CSF), with its ability to differentiate myelomonocytic leukemia cells in mice, was the first to be isolated (Burgess and Metcalf, 1980). The description of human G-CSF followed in 1985 (Nicola et al., 1985; Welte et al., 1985), and it became clear that G-CSF and GM-CSF were different cytokines (Metcalf, 1985; Sachs, 1987).
Source: Journal of Reproductive Immunology - Category: Allergy & Immunology Authors: Tags: Review Source Type: research