Medium-dose intravenous immunoglobulin therapy for women with six or more recurrent miscarriages

Recurrent miscarriage (RM) is defined as three or more consecutive pregnancy losses during early gestation and affects 1–1.8% of women (Laird et al., 2003). A wide variety of factors are involved in the pathogenesis of RM, including uterine anomalies, cervical incompetence, autoimmune diseases, antiphospholipid antibody, chromosomal abnormalities of couples, thrombophilic disorders, endocrinological abnormalities, and microbial infections. However, the etiology in approximately 50% of RM is unknown, and is thus designated as unexplained RM, which may be associated with aberrant immunity (Laird et al., 2003).

Source: Journal of Reproductive Immunology - February 20, 2015 Category: Allergy & Immunology Authors: Hideto Yamada, Masashi Deguchi, Yoko Maesawa, Yuki Nakajima, Yukari Nishino, Kenji Tanimura, Yasuhiko Ebina Source Type: research