Hypoxia Imaging in Gliomas With F-Fluoromisonidazole PET: Toward Clinical Translation

There is significant interest in the development of improved image-guided therapy for neuro-oncology applications. Glioblastomas (GBM) in particular present a considerable challenge because of their pervasive nature, propensity for recurrence, and resistance to conventional therapies. MRI is routinely used as a guide for planning treatment strategies. However, this imaging modality is not able to provide images that clearly delineate tumor boundaries and affords only indirect information about key tumor pathophysiology.

Source: Seminars in Nuclear Medicine - February 20, 2015 Category: Nuclear Medicine Authors: Christopher Bell, Nicholas Dowson, Mike Fay, Paul Thomas, Simon Puttick, Yaniv Gal, Stephen Rose Source Type: research