Optimizing Hypoxia Detection and Treatment Strategies

Clinical studies using Eppendorf needle sensors have invariably documented the resistance of hypoxic human tumors to therapy. These studies first documented the need for individual patient measurement of hypoxia, as hypoxia varied from tumor to tumor. Furthermore, hypoxia in sarcomas and cervical cancer leads to distant metastasis or local or regional spread, respectively. For various reasons, the field has moved away from direct needle sensor oxygen measurements to indirect assays (hypoxia-inducible factor–related changes and bioreductive metabolism) and the latter can be imaged noninvasively.
Source: Seminars in Nuclear Medicine - Category: Nuclear Medicine Authors: Source Type: research