The advanced glycation end product methylglyoxal-derived hydroimidazolone-1 and early signs of atherosclerosis in childhood diabetes

Conclusion: Serum levels of methylglyoxal-derived hydroimidazolone-1 in diabetes patients are increased and associated with low-grade inflammation, but not yet arterial stiffness or wall thickness. This indicates that methylglyoxal-derived hydroimidazolone-1 may be important in the early phase of the accelerated atherosclerotic process in diabetes.

http://dvr.sagepub.com/cgi/content/abstract/12/2/139?rss=1

Source: Diabetes and Vascular Disease Research - February 17, 2015 Category: Endocrinology Authors: Heier, M., Margeirsdottir, H. D., Torjesen, P. A., Seljeflot, I., Stensaeth, K. H., Gaarder, M., Brunborg, C., Hanssen, K. F., Dahl-Jorgensen, K. Tags: Original Articles Source Type: research