Cell ‐intrinsic Wnt4 promotes hematopoietic stem and progenitor cell self‐renewal

In conclusion, our results identify a new, largely autocrine role for Wnt4 in hematopoietic stem cell self ‐renewal, suggesting that regulation of Wnt signaling in hematopoiesis may not need Wnt secretion and could be independent of morphogen gradients.

Source: Stem Cells - April 29, 2021 Category: Stem Cells Authors: Roxann H étu‐Arbour, Mouna Tlili, Fabio Luiz Bandeira Ferreira, Belma Melda Abidin, Edward O. Kwarteng, Krista M. Heinonen Tags: Tissue ‐Specific Stem Cells Source Type: research