Sodium activates human monocytes via the NADPH oxidase and isolevuglandin formation

ConclusionHuman monocytes exhibit co-ordinated increases in parameters of activation, conversion to a DC-like phenotype and ability to activate T cells upon bothin vitro andin vivo sodium exposure. The ability of monocytes to be activated by sodium is related toin vivo cardiovascular disease risk factors. We therefore propose that in addition to the kidney and vasculature, immune cells like monocytes convey salt-induced cardiovascular risk in humans.
Source: Cardiovascular Research - Category: Cardiology Source Type: research