High sodium intake, glomerular hyperfiltration, and protein catabolism in patients with essential hypertension

ConclusionWhen exposed to high Na+ intake, kidneys dissociate Na+ and water handling. In hypertensive patients, this comes at the cost of higher glomerular filtration rate, increased tubular energy expenditure, and protein catabolism from endogenous (muscle) or excess exogenous (dietary) sources. Glomerular hyperfiltration and the metabolic shift may have broad implications on global cardiovascular risk independent of BP.
Source: Cardiovascular Research - Category: Cardiology Source Type: research