Msi1 inhibits cervical cancer cell apoptosis by downregulating BAK through AKT signaling

In this study, we found that the expression of Msi1 inhibited cervical cancer cell apoptosis in vitro and in vivo. Furthermore, the expression of Msi1 downregulated the expression of PTEN, while AKT signaling was activated, which resulted in a reduction in the proapoptotic protein BAK. In addition, rescue the expression of BAK in Msi1 expressing cervical cancer cells induced the increase of apoptosis cells. These findings indicate that Msi1 regulates cervical cancer cell apoptosis by inhibiting PTEN and activating AKT signaling, which leads to the downregulation of BAK.

Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Xian Liu, Yanru Zhang, PengSheng Zheng, Nan Cui Tags: Research Paper Source Type: research