Hsa_circ_0091581 promotes glioma progression by regulating RMI1 via sponging miR-1243-5p

This study demonstrated that hsa_circ_0091581 is upregulated in glioma tissues and cells. The results of the CCK-8, EdU, and transwell assays indicated that hsa_circ_0091581 promotes proliferation, migration, and invasion of glioma cells. The results of the luciferase reporter and RNA immunoprecipitation assays indicated that the mechanism of the effects of hsa_circ_0091581 on glioma cells involves sponging miR-1243-5p to regulate RMI1. The results of the rescue experiments indicated that hsa_circ_0091581 regulates proliferation, migration, and invasion of glioma cells by targeting RMI1 in a miR-1243-5p dependent manner. The results of the nude mice xenograft assays showed that knockdown of hsa_circ_0091581 inhibits glioma growth in vivo. Thus, our study determined the role of hsa_circ_0091581/miR-1243-5p/RMI1 in glioma and suggests that this axis may be a novel therapeutic target in glioma.

Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Jin Qian, Yingna Xu, Xing Xu, Zhenyu Tao, Yang Luo, Yichang Xu, Yong Zhang, Chunfa Qian Tags: Research Paper Source Type: research