Targeting miR-21 with NL101 blocks c-Myc/Mxd1 loop and inhibits the growth of B cell lymphoma

Conclusion: NL101 significantly inhibited the growth of B cell lymphoma in vitro and in vivo. The novel c-Myc/miR-21/Mxd1 positive-feedback loop is critical for the maintenance of B cell lymphoma survival. Targeting miR-21 to block c-Myc/miR-21/Mxd1 loop represents a novel potential strategy of c-Myc-directed therapy.

Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Shu Li, Xin He, Yichao Gan, Jiawei Zhang, Feiqiong Gao, Limin Lin, Xi Qiu, Teng Yu, Xuzhao Zhang, Panpan Chen, Jiefeng Tong, Wenbin Qian, Yang Xu Tags: Research Paper Source Type: research