Sunitinib-induced cardiac hypertrophy and the endothelin axis

Conclusion: Early metabolic changes predict sunitinib-induced cardiac remodeling. Endothelin blockade can prevent some but not all cardiotoxic side-effects of sunitinib, in particular left ventricle hypertrophy that appears to be induced by sunitinib through an endothelin-independent mechanism.

Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Joevin Sourdon, Caterina Facchin, Ana ï s Certain, Thomas Viel, Blaise Robin, Franck Lager, Carmen Marchiol, Daniel Balvay, Thulaciga Yoganathan, Judith Favier, Pierre-Louis Tharaux, Neeraj Dhaun, Gilles Renault, Bertrand Tavitian Tags: Research Paper Source Type: research