The short isoform of PRLR suppresses the pentose phosphate pathway and nucleotide synthesis through the NEK9-Hippo axis in pancreatic cancer

Conclusion: Our characterization of the relationship between PRLR-SF signaling, the NEK9-Hippo pathway, PPP and nucleotide synthesis explains a mechanism for the correlation between PRLR-SF and metabolic reprogramming in PDAC progression. Strategies to alter this pathway might be developed for the treatment or prevention of pancreatic cancer.

Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Huizhen Nie, Pei-Qi Huang, Shu-Heng Jiang, Qin Yang, Li-Peng Hu, Xiao-Mei Yang, Jun Li, Ya-Hui Wang, Qing Li, Yi-Fan Zhang, Lei Zhu, Yan-Li Zhang, Yanqiu Yu, Gary Guishan Xiao, Yong-Wei Sun, Jianguang Ji, Zhi-Gang Zhang Tags: Research Paper Source Type: research