Adenylosuccinate lyase is oncogenic in colorectal cancer by causing mitochondrial dysfunction and independent activation of NRF2 and mTOR-MYC-axis

Conclusions: Our results suggest that ADSL is a novel oncogene in CRC, modulating mitochondrial function, metabolism and oxidative stress, thus promoting cell cycle progression, proliferation and migration. Our results also suggest that ADSL is a predictive biomarker of response to 6-mercaptopurine in the pre-clinical setting.

Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Stephanie Taha-Mehlitz, Gaia Bianco, Mairene Coto-Llerena, Venkatesh Kancherla, Glenn R. Bantug, John Gallon, Caner Ercan, Federica Panebianco, Serenella Eppenberger-Castori, Marco von Strauss, Sebastian Staubli, Martin Bolli, Ralph Peterli, Matthias S. M Tags: Research Paper Source Type: research