Pectin supplement significantly enhanced the anti-PD-1 efficacy in tumor-bearing mice humanized with gut microbiota from patients with colorectal cancer

Conclusion: Pectin facilitated the anti-PD-1 mAb efficacy in CRC via regulating the T cell infiltration in the tumor microenvironment, which was potentially mediated by the metabolite butyrate.

Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Shi-Long Zhang, Yu-Qin Mao, Zheng-Yan Zhang, Zhan-Ming Li, Chao-Yue Kong, Hui-Ling Chen, Pei-Ran Cai, Bing Han, Tao Ye, Li-Shun Wang Tags: Research Paper Source Type: research