SARM1 promotes neuroinflammation and inhibits neural regeneration after spinal cord injury through NF- κ B signaling

Conclusion: Our results indicate that SARM1-mediated prodegenerative pathway and neuroinflammation promotes the pathological progress of SCI and anti-SARM1 therapeutics are viable and promising approaches for preserving neuronal function after SCI.

Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Huitao Liu, Jingjing Zhang, Xingxing Xu, Sheng Lu, Danlu Yang, Changnan Xie, Mengxian Jia, Wenbin Zhang, Lingting Jin, Xiwu Wang, Xiya Shen, Fayi Li, Wangfei Wang, Xiaomei Bao, Sijia Li, Minyu Zhu, Wei Wang, Ying Wang, Zhihui Huang, Honglin Teng Tags: Research Paper Source Type: research