SPTBN1 inhibits inflammatory responses and hepatocarcinogenesis via the stabilization of SOCS1 and downregulation of p65 in hepatocellular carcinoma
Conclusions: Our findings provided evidence that loss of SPTBN1 in HCC cells increases p65 protein stability via the inhibition of SOCS1 and enhances NF-κB activation, stimulating the release of inflammatory cytokines, which are critical molecular mechanisms for the loss of SPTBN1-induced liver cancer formation. Reduced SPTBN1 and SOCS1 predict poor outcome in HCC patients.
Source: Theranostics - Category: Molecular Biology Authors: Ling Lin, Shuyi Chen, Hua Wang, Bin Gao, Bhaskar Kallakury, Krithika Bhuvaneshwar, Katherine Cahn, Yuriy Gusev, Xue Wang, Yunan Wu, John L. Marshall, Xiuling Zhi, Aiwu Ruth He Tags: Research Paper Source Type: research
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