Dabigatran activates inflammation resolution by promoting fibrinogen-like protein 2 shedding and RvD5n-3 DPA production

Conclusions: Our findings identify the dual anti-inflammatory and pro-resolving actions of dabigatran, through promoting sFgl2-triggered RvD5n-3 DPA production, which has important implications for promoting tissue homeostasis of sepsis.

Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Juan Lei, Yu Zhou, Huakan Zhao, Yu Chen, Guifang Yan, Lei Wu, Yanquan Xu, Jiangang Zhang, Xiao Zhang, Jingchun Wang, Dingshan Li, Yongsheng Li Tags: Research Paper Source Type: research