Synthesis of RNA-based gene regulatory devices for redirecting cellular signaling events mediated by p53
Conclusion: The study developed a novel and efficient ribozyme switch for p53-specific recognition and provided a modular strategy for aptazyme binding to cellular proteins. In addition, the p53 aptazyme successfully inhibited tumor growth through a combined application with other synthetic biological tools, providing a new perspective for cancer therapy.
Source: Theranostics - Category: Molecular Biology Authors: Xinbo Huang, Mingxia Wang, Yuchen Liu, Yaoting Gui Tags: Research Paper Source Type: research
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