Deficiency of telomere-associated repressor activator protein 1 precipitates cardiac aging in mice via p53/PPAR α signaling

Conclusion: In summary, Rap1 may link telomere biology to fatty acid metabolism and aging-related cardiac pathologies via modulating the p53/PPARα signaling pathway, which could represent a therapeutic target in preventing/attenuating cardiac aging.

Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Yin Cai, Hao Liu, Erfei Song, Lin Wang, Jindong Xu, Yi He, Dengwen Zhang, Liyan Zhang, Kenneth King-yip Cheng, Leigang Jin, Min Wu, Shiming Liu, Dake Qi, Liangqing Zhang, Gary D. Lopaschuk, Sheng Wang, Aimin Xu, Zhengyuan Xia Tags: Research Paper Source Type: research