Vertebral-specific activation of the CX3CL1/ICAM-1 signaling network mediates non-small-cell lung cancer spinal metastasis by engaging tumor cell-vertebral bone marrow endothelial cell interactions

Conclusions: Our results indicated a unique feedback cycle between circulating NSCLC cells and VBMECs mediated by CX3CL1/ICAM-1 signaling, which is necessary for NSCLC spinal metastasis. This work provides a new perspective for underlying the mechanisms of NSCLC spinal metastasis and indicates potential novel targets for the prevention of NSCLC spinal metastasis.

Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Ketao Wang, Libo Jiang, Annan Hu, Chi Sun, Lei Zhou, Yiwei Huang, Qing Chen, Jian Dong, Xiaogang Zhou, Feng Zhang Tags: Research Paper Source Type: research