SIRT2 ablation inhibits glucose-stimulated insulin secretion through decreasing glycolytic flux

Conclusions: SIRT2 ablation inhibits GSIS through blocking GKRP protein degradation and promoting ALDOA protein degradation, resulting in a decrease in glycolytic flux.

Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Feiye Zhou, Linlin Zhang, Kecheng Zhu, Mengyao Bai, Yuqing Zhang, Qin Zhu, Shushu Wang, Chunxiang Sheng, Miaomiao Yuan, Yun Liu, Jieli Lu, Li Shao, Xiao Wang, Libin Zhou Tags: Research Paper Source Type: research