A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models

Conclusions: The PROTAC (C004019) created in the current study can selectively and efficiently promote tau clearance both in vitro and in vivo, which provides a promising drug candidate for AD and the related tauopathies.

Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Weijin Wang, Qiuzhi Zhou, Tao Jiang, Shihong Li, Jinwang Ye, Jie Zheng, Xin Wang, Yanchao Liu, Minmin Deng, Dan Ke, Qun Wang, Yipeng Wang, Jian-Zhi Wang Tags: Research Paper Source Type: research