CD45RO-CD8+ T cell-derived exosomes restrict estrogen-driven endometrial cancer development via the ER β /miR-765/PLP2/Notch axis

Conclusions: This observation reveals novel molecular mechanisms underlying estrogen signaling and CD8+ T cell-released exosomes in UCEC development, and provides a potential therapeutic strategy for UCEC patients with aberrant ERβ/miR-765/PLP2/Notch signaling axis.

Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Wen-Jie Zhou, Jie Zhang, Feng Xie, Jiang-Nan Wu, Jiang-Feng Ye, Jian Wang, Ke Wu, Ming-Qing Li Tags: Research Paper Source Type: research