An integrated epigenomic-transcriptomic landscape of lung cancer reveals novel methylation driver genes of diagnostic and therapeutic relevance

Conclusions: We discovered several novel methylation driver genes of diagnostic and therapeutic relevance in lung cancer. Our findings revealed that DNA methylation in TF binding motifs regulates target gene expression by affecting the binding ability of TFs. Our study also provides a valuable epigenetic resource for identifying DNA methylation-based diagnostic biomarkers, developing cancer drugs for epigenetic therapy and studying cancer pathogenesis.

Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Xiwei Sun, Jiani Yi, Juze Yang, Yi Han, Xinyi Qian, Yi Liu, Jia Li, Bingjian Lu, Jisong Zhang, Xiaoqing Pan, Yong Liu, Mingyu Liang, Enguo Chen, Pengyuan Liu, Yan Lu Tags: Research Paper Source Type: research