Identification of the canonical and noncanonical role of miR-143/145 in estrogen-deficient bone loss

Conclusions: Our findings reveal a canonical and noncanonical role of miR-143/145 in controlling BMSCs pluripotency and unfold their dual effect on bone formation and bone resorption, suggesting miR-143/145 as promising therapeutic targets for treating estrogen-deficient bone loss.

Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Rongyao Xu, Xin Shen, Hanyu Xie, Hengguo Zhang, Dingshan Liu, Xin Chen, Yu Fu, Ping Zhang, Yi Yang, Jie Cheng, Hongbing Jiang Tags: Research Paper Source Type: research