Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth

Conclusions: This is the first demonstration that HER3 can be targeted with small molecules by eliminating it from the cell membrane. The novel approach used here led to the discovery that perhexiline ablates HER3 expression, and offers an opportunity to identify HER3 ablation modulators as innovative therapeutics to improve survival in breast cancer patients.
Source: Breast Cancer Research - Category: Cancer & Oncology Authors: Source Type: research