Transfusions for anemia in adult and pediatric patients with malignancies
Anemia is present in over two-thirds of patients with malignant hematological disorders. The etiology of anemia predominates from ineffective erythropoiesis from marrow infiltration, cytokine related suppression, erythropoietin suppression, and vitamin deficiency; ineffective erythropoiesis is further exacerbated by accelerated clearance due to antibody mediated hemolysis and thrombotic microangiopathy. As the anemia is chronic in nature, symptoms are generally well tolerated and often non-specific.
Source: Blood Reviews - Category: Hematology Authors: Neil Shah, Jennifer Andrews, Lawrence Tim Goodnough Tags: REVIEW Source Type: research