Circulating levels of fibroblast growth factor-21 increase with age independently of body composition indices among healthy individuals

Conclusions Our findings in a healthy population display an age-related increase in serum FGF21, highlighting a potential age effect in response to metabolic demand over the lifecourse. FGF21 levels increase with age independently of body composition. At lower levels of FGF21, BMD, but not other body composition parameters, attenuates the association between FGF21 level and age, suggesting the metabolic demand of the skeleton may provide a link between FGF21 and energy metabolism.
Source: Journal of Clinical and Translational Endocrinology - Category: Endocrinology Source Type: research