Pharmacokinetics of intravenous and oral amitriptyline and its active metabolite nortriptyline in Greyhound dogs

Conclusions and clinical relevanceAmitriptyline at 4 mg kg−1 administered orally produced low amitriptyline and nortriptyline plasma concentrations. This brings into question whether the currently recommended oral dose of amitriptyline (1–4 mg kg−1) is appropriate in dogs.

Source: Veterinary Anaesthesia and Analgesia - January 1, 2015 Category: Veterinary Research Authors: Christopher Norkus, David Rankin, Butch KuKanich Tags: Research Paper Source Type: research