Engineered human cardiac microtissues: The state ‐of‐the‐(he)art

The recent advances in cardiac microtissue engineering focused on approaches to recapitulate the adult heart and disease phenotype. The microtissue platform depicted may not be representative of platform used in selected publication and is only a generalization. AbstractDue to the integration of recent advances in stem cell biology, materials science, and engineering, the field of cardiac tissue engineering has been rapidly progressing toward developing more accurate functional 3D cardiac microtissues from human cell sources. These engineered tissues enable screening of cardiotoxic drugs, disease modeling (eg, by using cells from specific genetic backgrounds or modifying environmental conditions) and can serve as novel drug development platforms. This concise review presents the most recent advances and improvements in cardiac tissue formation, including cardiomyocyte maturation and disease modeling.© AlphaMed Press 2021Significance StatementThis concise review seeks to highlight the recent advances in in vitro cardiac tissue models as a platform for understanding cardiac function and pathology and a tool for therapeutic assessment.
Source: Stem Cells - Category: Stem Cells Authors: Tags: Regenerative Medicine Source Type: research