Susceptibility to cancer of the first-degree relatives of HNSCC patients being tobacco consumers and carrying both GSTM1-GSTT1 null genotypes.

Conclusion: Our study suggests thatGSTM1 and GSTT1 null genotypes and tobacco consumption increase the risk of HNSCC. Furthermore, it revealed that the first-degree relatives of HNSCC patients highly susceptible to cancer if they carry both GSTM1 and GSTT1 null genotype and as well expose to tobacco.
Source: Head and Neck Oncology - Category: Cancer & Oncology Source Type: research