Expression of Epstein-Barr virus-encoded BamH1–a rightward transcript 7 microRNA in nasopharyngeal carcinoma cells modulates the responsiveness to irradiation treatment.

Conclusion Our results suggest that patients with nasopharyngeal carcinoma have elevated ebv-miR-BART7 expression levels in the primary and recurrent nasopharyngeal carcinoma tissues. Higher expression of ebv-miR-BART7 increased the sensitivity of nasopharyngeal carcinoma cells to irradiation treatment. Further investigation with regard to the clinical value of ebv-miR-BART7 to aid therapeutic response is warranted in order to evaluate the potential use of ebv-miR-BART7 as a molecular biomarker in monitoring patients with nasopharyngeal carcinoma.
Source: Head and Neck Oncology - Category: Cancer & Oncology Source Type: research