Primary capicua transcriptional repressor-rearranged sarcoma of the lung

AbstractA 60-year-old man had a malignant left lower lung tumour with no metastases and underwent video-assisted thoracoscopic left lower lobectomy and lymphadenectomy. Pathological examination led to a diagnosis of capicua transcriptional repressor (CIC)-rearranged sarcoma. He has had 3.5  years of recurrence-free survival.CIC-rearranged sarcoma is a Ewing-like sarcoma that shows pathological findings similar to Ewing sarcoma. Most ofCIC-rearranged sarcoma isCIC-double homeobox 4 protein (DUX4) fusion. PulmonaryCIC-rearranged sarcoma is extremely rare and has an unfavourable prognosis. However, complete resection can produce prognosis of long-term survival, and thus, surgery is an important option.
Source: Japanese Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research