Attenuation of inflammatory and neuropathic pain behaviors in mice through activation of free fatty acid receptor GPR40

Conclusions:
Our results indicate that GPR40 signaling pathway plays an important suppressive role in spinal nociceptive processing after inflammation or nerve injury, and that GPR40 agonists might serve as a new class of analgesics for treating inflammatory and neuropathic pain.

Source: Molecular Pain - February 12, 2015 Category: Molecular Biology Authors: Prasanna KarkiTakashi KuriharaTomoya NakamachiJun WatanabeToshihide AsadaTatsuki OyoshiSeiji ShiodaMegumu YoshimuraKazunori AritaAtsuro Miyata Source Type: research