Recurrence of disease activity after fingolimod discontinuation in older patients previously stable on treatment.: All patients with FTY withdrawal(n=128)Age (y) at disease onset (mean, SD)32.4, 8.9Sex, F/M (n)94/34Positive OCB (%)95.6Prior treatment (n, %)Treatment naiveFirst lineNTZOther 2d line56/128, 43.8 %59/128, 46.1 %11/128, 8.6 %2/128, 1.6 %Disease activity prior to FTY initiation Highly active patients (n, %)26/128, 20.3 %Relapses (mean, SD) 1, 0.9EDSS (median, range)2, 1-6.5No of new T2 lesions (mean, SD)4.7, 10.2No of Gd enhancing lesions (mean, SD)1.7, 5.6NEDA-3 status on FTY treatment (n, %)73/128, 57 %Age (y) at FTY discontinuation (mean, SD)41.6, 11Treatment duration (months) (mean, SD)40.3, 25.3Wash out period (days) (mean, SD)59.5, 44.1Age at fingolimod discontinuationYounger patients(n=52)Older patients(n=21) P valueAge (y) at disease onset (mean, SD)31.1, 741.1, 8.4<0.001Age (y) at FTY discontinuation(mean, SD)38.4, 7.756.8, 5<0.001Prior treatment (n, %)Treatment naiveFirst linePrevious NTZCladribine25/52, 58.124/52, 46.22/52, 3.81/52, 1.94/21, 1914/21, 66.71/21, 4.81/21, 4.80.119Disease activity prior to FTY initiation(mean, SD)RelapsesEDSS (median, range)No of new T2 lesionsNo of Gd enhancing lesions0.9, 11.5, 1-6.53.5, 71, 2.30.5, 0.72, 1.5-6.51.9, 3.20.5, 1.20.1010.2170.2080.226Treatment duration (m), (mean, SD)37.6, 29.646.8, 20.20.131Wash-out period (days) (mean, SD)90.8, 6767.7, 29.20.138Disease activity after FTY discontinuation (mean, SD)RelapsesEDSS 0.3, 0.61,5, 0-80.1, 0.32.0, 1-6.50.0690.051No of new T2 lesionsNo of Gd enhancing lesions3.5, 8.62.8, 8.50.6, 1.80.4, 1.40.0710.101DMT relay (n, %)NoneIFNDMFTRFNTZAnti-CD2032/52, 61.53/52, 5.83/52, 5.89/52, 17.31/52, 1.94/52, 7.74/21, 1905/21, 23.89/21, 42.903/21,14.30.013

Publication date: Available online 21 March 2021Source: Multiple Sclerosis and Related DisordersAuthor(s): Vasiliki Pantazou, Caroline Pot, Renaud Du Pasquier, Géraldine Le Goff, Marie Théaudin
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research