Predictability of Elimination and Excretion of Small Molecules from Animals to Humans, and Impact on Dosimetry for human ADME Studies with Radiolabeled Drugs

CONCLUSION: In all cases where the plasma elimination half-life for 14C in humans was found to be longer than the predicted value, the radiation burden was still within ICRP Category IIa. Containment of the actual radiation burden below the limit of 1.00 mSv appeared to be determined partly also by our choice to limit 14C doses to 3.7 MBq.PMID:33687900 | DOI:10.2174/1574884716666210309103625

Source: Current Clinical Pharmacology - March 10, 2021 Category: Drugs & Pharmacology Authors: Ad Roffel Jan Jaap van Lier Gerk Rozema Ewoud-Jan van Hoogdalem Source Type: research