T Allele of the DRD2 Taq1A Gene Polymorphism Increases the Predisposition to Drug Addiction in Indonesian Population

This study will focus on the frequency of the DRD2 Taq1A gene polymorphism in the population of Indonesia and define its association with drug addiction. Methods: This is a cross sectional study in which 182 subjects were divided into 91 drugaddicted patients and 91 non-drug-addicted control subjects. The genotype analysis was carried out by a modified allele-specific Polymerase Chain Reaction (PCR) method. Results: The frequency of the T/T and C/T was significantly higher in the addicted than control subjects. They are 6.6% and 63.7% compared to 0% and 3.3%. Likewise, the T allele is more frequent in the addicted equal to 38%, compared to only 2% in the control subjects. The frequency of the T allele between the addicted and control subjects shows a significant difference (p-value
Source: Current Pharmacogenomics and Personalized Medicine - Category: Genetics & Stem Cells Source Type: research