Immunohistochemical Markers in lymphoid Malignancies: Protein Correlates of molecular alterations

Histomorphology, immunohistochemistry (IHC), and genetics are essential tools for the evaluation and classification of lymphoid malignancies. Advances in diagnostic techniques include the development of immunohistochemical assays that can serve as surrogates for genetic tests. We review the performance of select subset of assays that detect the aberrant expression of onco-proteins secondary to chromosomal translocations (MYC; BCL2), somatic mutations (BRAF V600E; NOTCH1), and gene copy number gains (PD-L1; PD-L2) in fixed tissue biopsy sections.
Source: Seminars in Diagnostic Pathology - Category: Pathology Authors: Source Type: research