IGF2 signaling and regulation in cancer

The mitogenic peptide IGF2 is a component of the phylogenetically ancient insulin/IGF-signaling axis that regulates cell survival, growth and proliferation, and metabolism. Other IGF-axis components include the related peptide IGF1, IGF2 mRNA binding proteins (IGF2BPs, IMPs) and IGF binding proteins (IGFBPs) that regulate IGFs post-transcriptionally and post-translationally, as well as the IGF receptors IGF1R and IGF2R. As the name indicates, insulin and IGF peptides, as well as their receptors IR and IGF1R, share significant sequence homology.
Source: Cytokine and Growth Factor Reviews - Category: Molecular Biology Authors: Tags: Mini review Source Type: research