The essential role of long non-coding RNA GAS5 in glioma: interaction with microRNAs, chemosensitivity and potential as a biomarker

Glioma is a malignant brain tumor with a generally poor prognosis. Dysregulation of a long non-coding RNA, GAS5, has been detected in numerous cancers, including glioma. Previous studies have suggested that GAS5 plays a significant functional role in glioma, affecting proliferation, metastasis, invasion, and apoptosis. In this review, we describe the roles and mechanisms of GAS5 in glioma. GAS5 may be a biomarker for diagnosis and prognosis, and even a potential target for glioma treatment, and therefore warrants further investigation.

Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Xuewen Tan, Haifeng Jiang, Yilong Fang, Dafei Han, Yawei Guo, Xinming Wang, Xun Gong, Wenming Hong, Jiajie Tu, Wei Wei Tags: Review Source Type: research