Synthesis and evaluation of 68Ga-labeled dimeric cNGR peptide for PET imaging of CD13 expression with ovarian cancer xenograft

Conclusions: 68Ga-DOTA-c(NGR)2 was easily synthesized, and it showed favorable CD13-specific targeting ability by in vitro data and microPET imaging with ovarian cancer xenografts. Collectively, 68Ga-DOTA-c(NGR)2 might be a potential PET imaging probe for non-invasive evaluation of the CD13 receptor expression in tumors.

Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Yi Yang, Jun Zhang, Huifeng Zou, Yang Shen, Shengming Deng, Yiwei Wu Tags: Research Paper Source Type: research