TDP-43 proteinopathy impairs mRNP granule mediated postsynaptic translation and mRNA metabolism

Conclusion: Our study elucidates the interplay between TDP-43 and neuronal mRNP granules in normal physiology and TDP-43 proteinopathy in the regulation of local protein translation and mRNA metabolism in the postsynaptic compartment.

Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Chia-En Wong, Lee-Way Jin, Yuan-Ping Chu, Wei-Yen Wei, Pei-Chuan Ho, Kuen-Jer Tsai Tags: Research Paper Source Type: research