Inter and intra-tumor somatostatin receptor 2 heterogeneity influences peptide receptor radionuclide therapy response

Conclusion: Heterogeneous SST2 expression levels within NETs cause differentially induced DNA damage levels, influence recurrent tumor phenotypes and impact the therapeutic response in different models and potentially in patients. Our results contribute to a better understanding of PRRT effects, which might impact future therapeutic outcome of NET patients.

Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Danny Feijtel, Gabriela N. Doeswijk, Nicole S. Verkaik, Joost C. Haeck, Daniela Chicco, Carmelina Angotti, Mark W. Konijnenberg, Marion de Jong, Julie Nonnekens Tags: Research Paper Source Type: research