Enhanced neprilysin-mediated degradation of hippocampal A β 42 with a somatostatin peptide that enters the brain

Conclusion: With intravenous injections of our BBB permeable SST peptide, we were able to significantly increase the levels neprilysin, an effect that was followed by a significant and selective degradation of membrane-bound Aβ42 in the hippocampus. Being that membrane-bound Aβ triggers neuronal toxicity and the hippocampus is the central brain area in the progression of AD, the study has illuminated a new potential treatment paradigm with a promising safety profile targeting only the disease affected areas.

Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Fadi Rofo, Canan Ugur Yilmaz, Nicole Metzendorf, Tobias Gustavsson, Chiara Beretta, Anna Erlandsson, Dag Sehlin, Stina Syv ä nen, Per Nilsson, Greta Hultqvist Tags: Research Paper Source Type: research