Covalent modification of Keap1 at Cys77 and Cys434 by pubescenoside a suppresses oxidative stress-induced NLRP3 inflammasome activation in myocardial ischemia-reperfusion injury

Conclusions: Our results indicated that PBA might be a new Nrf2 activator that covalently binds to two critical domains of Keap1, and shows cardioprotective activities against ischemia-reperfusion injury.

Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Yuanyuan Cheng, Liangkai Cheng, Xiang Gao, Sixuan Chen, Peng Wu, Caiyan Wang, Zhongqiu Liu Tags: Research Paper Source Type: research